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Trial of a new type treatment for Alzheimer's. Alzheimer's disease is one of the most prevalent and debilitating neurodegenerative diseases. A new treatment, called 'vacuolating' or 'vacuum-assisted' treatment with a drug (vacuolizumab), is being studied by two universities. The technique is very simple, and may therefore be effective against other brain diseases (such as Alzheimer's) well. The trial is on in US. If it is found to be effective, a possible patent could be awarded. A total of 50 patients were given either vacuolizumab or a placebo, and the patients were followed for a year. It has been found that the patients who had received treatment lost an average of three years, compared to those who had the placebo.
The trial's results were published in the journal PloS One, and were reported in the British Journal of Alzheimer's Disease. The researchers at University of North Carolina and the University of Cincinnati also published a paper about the results in November. They write, "We hope that this study will encourage the development of innovative treatments for these and other neurodegenerative diseases."
Why is vacuolating effective?
The researchers believe that vacuolating therapy works because it breaks down the toxic proteins in brain more quickly.
Vacuolizumab (VX-809) is used in combination with another drug (befitinib), which also increases the body's own production of another protein that is toxic to the brain.
The study was part of a larger NIH-funded trial called BACE3, which is trying to find a new method prevent the development of Alzheimer's. researchers found that the brain cells of people with Alzheimer's disease are affected by the toxic proteins made their own immune system.
The vacuolating therapy works by breaking down these toxins, and making it immune cells that the body can control better.
Who is being treated?
The researchers hope that results of the trial will help boost chances of finding a treatment for Alzheimer's, and other forms of neurodegenerative disease. The trial is being conducted on 50 people buy motilium online canada
with Alzheimer's disease.
It is particularly important to look more closely at possible treatments for Alzheimer's because so few drugs currently exist. Currently, the only treatment is a kind of drugs known as 'triple-drug therapy'. Those drugs are the so-called 'triclosan' compounds, which are used to prevent bacteria from getting into the body.
Triple-drug therapy may not work for all cases of Alzheimer's disease.
The trial's trial design was based on the results of a study from 2013, in which more than 1,500 people with Alzheimer's disease were treated and found to have a higher rate of brain volume loss than healthy people.
However, in that study the researchers also looked at whether there was any difference between those who had a treatment with triptorelin and those who did not. Results showed that there was no difference.
In the next phase of study it will be a couple of Buy motilium instants uk
years before the results are known, as researchers will continue to monitor the patients.
What are the main risks?
The main risk associated with vacuolating is the possible side effects. When a person is given the drug, a blood thinner called warfarin (Coumadin) is given to prevent the blood from clotting. If bleeding process is not stopped, it can lead to kidney failure.
Other side effects of the treatment include an increased risk of blood clots and high pressure.
What are the benefits?
The researchers say that study could be very beneficial to patients with Alzheimer's disease, as a large number of studies over the past 30 years have led to very little progress in the treatment of disease.
This study could pave the way for a new treatment Alzheimer's disease, in which there are currently no drugs on the market.
The study is funded by NIHR Biomedical Research Centre, the pharmacy online coupon National Institute for Health Research, the NIHR Biomedical Research Centre Clinical Centre, and the NIHR Biomedical Research Centre Clinical Unit.
Featured image credit: Alok Sharma, CC BY-SA
This post is part of our contributor series. It is written and published independently of TNW.
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